Baroreflex inhibition during coronary occlusion is mediated by prostaglandins
Key result
Indomethacin abolished the 75% reduction in the baroreflex slope during coronary occlusion in intact dogs, indicating that baroreflex inhibition is mediated by prostaglandins.
Why the study?
Does indomethacin prevent the attenuation of baroreflex control of renal sympathetic nerve activity during acute coronary artery occlusion in dogs?
Population
Dogs (intact, vagotomized, and thoracic-sympathectomized)
Comparison
Indomethacin administered prior to a 5- to… vs Same protocol before indomethacin treatment
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Supports prostaglandin mediation of ischemia-induced baroreflex inhibition in dogs; leaves open translation to human coronary syndromes.
Structured PICO
Does indomethacin prevent the attenuation of baroreflex control of renal sympathetic nerve activity during acute coronary artery occlusion in dogs?
P
Population
Experimental study in dogs evaluating the role of cardiac prostaglandins in baroreflex control during acute coronary artery occlusion.
I
Intervention
Indomethacin (5 mg/kg) administered prior to a 5- to 10-min occlusion of the left circumflex coronary artery with arterial pressure lowered by sodium nitroprusside infusion
C
Comparator
Same protocol before indomethacin treatment
O
Outcome
Slope of the mean arterial pressure-renal sympathetic nerve activity (RSNA) relationshipsurrogate
Cyclooxygenase products, likely prostaglandins, released during coronary ischemia stimulate cardiac vagal afferents to attenuate baroreflex-mediated increases in renal sympathetic nerve activity.
Cite This Study
Zucker et al. (1989) studied Acute coronary artery occlusion. Indomethacin vs. Before indomethacin treatment was evaluated on Slope of the mean arterial pressure-renal sympathetic nerve activity (RSNA) relationship. Indomethacin abolished the 75% reduction in the baroreflex slope during coronary occlusion in intact dogs, indicating that baroreflex inhibition is mediated by prostaglandins.