Key result
Indomethacin reversed the attenuation of the baroreflex control of renal sympathetic nerve activity during reperfusion of short-term ischaemic myocardium in anaesthetized rabbits.
Why the study?
Does blockade of prostaglandin synthesis with indomethacin reverse the inhibitory baroreflex during reperfusion of short-term ischaemic myocardium in rabbits?
Population
Anaesthetized rabbits (intact and vagotomized)
Comparison
Indomethacin administered 20 min prior to testing vs Indomethacin vehicle (50 mmol/L trisaminomethane…
Design
Preclinical
Authors
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Baroreflex impairment during reperfusion may involve prostaglandins; leaves open relevance to human ischemia or therapy.
Does blockade of prostaglandin synthesis with indomethacin reverse the inhibitory baroreflex during reperfusion of short-term ischaemic myocardium in rabbits?
p-value: p=< 0.05
Prostaglandins released by ischaemic myocardium attenuate the baroreflex-mediated response of renal sympathetic nerve activity to lowered arterial pressure via vagal afferents during reperfusion.
Wang et al. (2000) studied Ischaemic myocardium. Indomethacin vs. Indomethacin vehicle was evaluated on Slope of the mean arterial pressure (MAP)-RSNA relationship (p=< 0.05). Indomethacin reversed the attenuation of the baroreflex control of renal sympathetic nerve activity during reperfusion of short-term ischaemic myocardium in anaesthetized rabbits.
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