Key result
Coronary occlusion reduced the baroreflex slope to 18.8 +/- 3.8 ms.kPa-1 compared with 41.4 +/- 6.0 ms.kPa-1 at the control state in conscious dogs.
Why the study?
Does coronary occlusion alter arterial baroreflex control of heart rate in conscious dogs?
Population
9 conscious dogs
Comparison
Coronary occlusion (acute myocardial ischaemia) vs Control state (baseline) and recovery phase
Design
Preclinical
Authors
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Indicates ischemia blunts baroreflex gain in conscious dogs; leaves open translation to human acute coronary syndromes.
Does coronary occlusion alter arterial baroreflex control of heart rate in conscious dogs?
Absolute Event Rate: 18.8% vs 41.4%
Acute myocardial ischemia reduces the baroreflex slope in conscious dogs, an effect that persists after beta-blockade, suggesting modulation by cardiac receptors.
Takeshita et al. (1980) studied Acute myocardial ischaemia (n=9). Coronary occlusion vs. Control state was evaluated on Baroreflex slope. Coronary occlusion reduced the baroreflex slope to 18.8 +/- 3.8 ms.kPa-1 compared with 41.4 +/- 6.0 ms.kPa-1 at the control state in conscious dogs.
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