Why the study?
Does cardiopulmonary bypass under moderate hypothermia alter the pharmacokinetics of propranolol in patients undergoing CABG?
Population
11 patients, mean age 57 +/- 8 years, undergoing coronary artery bypass grafting by cardiopulmonary bypass…
Comparison
Propranolol administered before surgery and… vs Pre-operative pharmacokinetic parameters
Design
Cohort
Follow-up
postoperative period
Authors
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May warrant dosing caution with propranolol after CABG with CPB; leaves open confirmation in prospective PK studies.
Does cardiopulmonary bypass under moderate hypothermia alter the pharmacokinetics of propranolol in patients undergoing CABG?
Cardiopulmonary bypass under moderate hypothermia significantly increases the biological half-life and volume of distribution of propranolol, which may lead to unpredictable postoperative hemodynamic responses.
Carmona et al. (2005) studied this question.
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