Why the study?
Does cardiopulmonary bypass alter the pharmacokinetics of propranolol and atenolol in patients undergoing CABG?
Population
19 patients undergoing coronary artery bypass graft surgery with moderately hypothermic cardiopulmonary…
Comparison
Cardiopulmonary bypass (CPB) during CABG surgery vs Pre-operative pharmacokinetic baseline
Design
Cohort
Follow-up
first day after surgery
Authors
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CPB may prolong propranolol effects after CABG; leaves open optimal beta-blocker selection pending prospective PK trials.
Does cardiopulmonary bypass alter the pharmacokinetics of propranolol and atenolol in patients undergoing CABG?
Cardiopulmonary bypass significantly alters the pharmacokinetics of propranolol, but not atenolol, which may lead to unexpected long-lasting effects postoperatively.
Carmona et al. (2009) studied this question.
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