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January 7, 2009Medical Engineering & Physics

The influence of plaque composition on underlying arterial wall stress during stent expansion: The case for lesion-specific stents

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Population

Idealised finite element model of a stenosed artery with different plaque types

Comparison

Balloon expandable coronary stent implantation… vs Comparison across different plaque types and…

Design

Preclinical

Authors

IPIan Owens PericevicCLCaitríona LallyTrinity CollegeDTDeborah Toner

Discussion

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Implication

May inform plaque-specific stenting pressures in models; leaves open in vivo validation and clinical translation.

Structured PICO

P
Population
Idealised finite element model of a stenosed artery with different plaque types (hypercellular, hypocellular, and calcified)
I
Intervention
Balloon expandable coronary stent implantation at inflation pressures of 9, 12, and 15 atm
C
Comparator
Comparison across different plaque types and inflation pressures
O
Outcome
Vessel and plaque stresses during stent implantationsurrogate

Computational modeling suggests that plaque composition significantly influences arterial wall stress during stenting, with calcified plaques potentially allowing higher inflation pressures with lower risk of arterial injury.

Cite This Study

Pericevic et al. (2009) studied this question.

synapsesocial.com/papers/6a71a8ee439bab0cabc3a423https://doi.org/10.1016/j.medengphy.2008.11.005
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Structure-dependent dynamic mechanical behavior of fibrous caps from human atherosclerotic plaques.1991 · 371 citations
  2. 2Analysis of Prolapse in Cardiovascular Stents: A Constitutive Equation for Vascular Tissue and Finite-Element Modelling2003 · 181 citations
  3. 3High‐resolution MR imaging of human arteries1995 · 112 citations
  4. 4Intracoronary Stenting and Angiographic Results2001 · 949 citations