Key result
Telmisartan (1 μmol/L) reduced monocytic cell adhesion to endothelial cells exposed to non-uniform shear stress and TNF-alpha by about 45%, mediated by reduced VCAM-1 expression.
Why the study?
Does telmisartan reduce monocytic cell adhesion and VCAM-1 expression in human umbilical vein endothelial cells exposed to non-uniform shear stress and TNF-alpha?
Population
Human umbilical vein endothelial cells in an in vitro model of arterial bifurcations exposed to non-uniform…
Comparison
Telmisartan administered during 18 h exposure to… vs Control and/or co-administration with PPAR-gamma…
Design
Preclinical
Authors
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Hypothesis-generating for telmisartan's pleiotropic vascular effects; leaves open clinical translation in atherosclerosis.
Does telmisartan reduce monocytic cell adhesion and VCAM-1 expression in human umbilical vein endothelial cells exposed to non-uniform shear stress and TNF-alpha?
Telmisartan decreases TNF-alpha-induced monocytic cell recruitment and VCAM-1 expression in endothelial cells under non-uniform shear stress via PPAR-gamma activation, suggesting a pleiotropic anti-atherosclerotic mechanism.
Cicha et al. (2011) studied Atherosclerosis (in vitro model). Telmisartan vs. Untreated cells was evaluated on Monocytic cell adhesion. Telmisartan (1 μmol/L) reduced monocytic cell adhesion to endothelial cells exposed to non-uniform shear stress and TNF-alpha by about 45%, mediated by reduced VCAM-1 expression.
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