Key result
Ischemic cardiomyopathy in coronary heart disease patients was associated with elevated bone marrow IFN-γ levels (10.00 vs 0.02 pg/ml, p<0.01) and impaired differentiation of mature monocyte forms.
Why the study?
Impaired differentiation of monocyte subpopulations may contribute to ischemic cardiomyopathy, but the humoral cytokine-dependent regulation of bone marrow monocyte differentiation in CHD patients with or without ICMP required investigation.
Observational (n=45)
No
Absolute Event Rate: 10% vs 0.02%
p-value: p=<0.01
Ischemic cardiomyopathy is associated with impaired bone marrow differentiation of classical and intermediate monocytes, driven by local hypersecretion of IFN-γ and a decreased M-CSF/IL-13 ratio.
May implicate IFN-γ-driven inflammation in ischemic cardiomyopathy; hypothesis-generating and requires prospective validation.
Background: Monocytes and macrophages play an important role in atherogenesis and myocardial remodeling. Impaired differentiation of monocyte subpopulations may contribute to ischemic cardiomyopathy (ICMP). The aim of the present research was to study the features of the humoral cytokine-dependent regulation of differentiation of classical, intermediate, non-classical and transitional monocytes in bone marrow (BM) of CHD patients with or without ICMP.
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Уразова et al. (2019) conducted an observational in Coronary heart disease with or without ischemic cardiomyopathy (n=45). Ischemic cardiomyopathy vs. Coronary heart disease without ischemic cardiomyopathy was evaluated on Bone marrow concentration of IFN-γ (pg/ml) (p=<0.01). Ischemic cardiomyopathy in coronary heart disease patients was associated with elevated bone marrow IFN-γ levels (10.00 vs 0.02 pg/ml, p<0.01) and impaired differentiation of mature monocyte forms.
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