Key result
Review outlines the roles of monocyte subsets and inflammatory markers in HFpEF and HFrEF.
Why the study?
Monocytes are heterogeneous with varying functions in cardiovascular disease, and whether monocyte and macrophage functions are a cause or consequence in CHF development remains an open question.
This review summarizes current evidence on the phenotypic and functional heterogeneity of monocyte subsets in chronic heart failure, highlighting their distinct roles in HFpEF and HFrEF pathogenesis.
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Monocyte heterogeneity may guide HF subtype phenotyping; hypothesis-generating and requires prospective validation before clinical use.
Mongirdienė et al. (2021) conducted a review in Chronic heart failure (HFpEF and HFrEF). Monocyte subsets was evaluated. This review summarizes current studies on the function of various monocyte subsets in chronic heart failure, focusing on their roles in HFpEF and HFrEF and their relation to inflammatory markers.
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