What does this research mean for the field?

Monocytes and their distinct subsets play a pivotal role in the inflammatory cascade underlying heart failure pathophysiology, driving tissue damage and repair processes that impact myocardial performance. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

September 28, 2011European Journal of Heart Failure

The Role of Monocytes and Inflammation in the Pathophysiology of Heart Failure

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Population

Patients with heart failure

Design

Review

Authors

Benjamin WrigleyInterventional / Structural Cardiology

Gregory Y.H. LipElectrophysiology

Eduard ShantsilaGeneral / Preventive / Lipids

Discussion

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Implication

Monocyte-targeted anti-inflammatory strategies lack proven benefit in heart failure; leaves open the need for dedicated trials.

Structured PICO

Population

Patients with heart failure

This review highlights the pivotal role of monocytes and inflammation in the pathophysiology of heart failure, including their activation, recruitment, and potential as therapeutic targets.

Cite This Study

Wrigley et al. (2011) studied this question.

synapsesocial.com/papers/69c3a33cb51fd8dfa997f558 https://doi.org/10.1093/eurjhf/hfr122

Topics

Heart failure HFrEF treatment

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The Role of Monocytes and Inflammation in the Pathophysiology of Heart Failure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

The Role of Monocytes and Inflammation in the Pathophysiology of Heart Failure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider