Monocytes in heart failure: relationship to a deteriorating immune overreaction or a desperate attempt for tissue repair?
Why the study?
What is the role of monocytes in heart failure, and should monocyte activation be considered a therapeutic target?
Structured PICO
What is the role of monocytes in heart failure, and should monocyte activation be considered a therapeutic target?
P
Population
Patients with heart failure (conceptual review)
I
Intervention
Monocyte activation or suppression (conceptual therapeutic targets)
This review highlights the dual role of monocytes in heart failure, suggesting that promoting their tissue repair functions could be a novel therapeutic strategy.
Authors
Discussion
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Implication
Does not support altering monocyte therapies in HF practice; leaves open activation strategies for prospective trials.
Cite This Study
Apostolakis et al. (2009) studied this question.