Key result
Poly(methylmethacrylate-co-acrylic acid) copolymers were synthesized and investigated for their physicochemical properties, adhesiveness, and drug release kinetics as potential stent coatings.
Poly(methylmethacrylate-co-acrylic acid) copolymers show potential as drug-eluting coatings for vascular stents.
These copolymers merit further preclinical testing; leaves open any role in clinical stent coatings.
The aim of the present work is the synthesis and characterization of polymer materials showing good adhesion, drug loading, and delivery properties, for potential cardiovascular application. In particular, poly(methylmethacrylate-co-acrylic acid) copolymers are prepared in different compositions by a radical polymerization and investigated as potential materials to coat metallic stents and to carry out a local drug release. Films obtained by dissolving the copolymer in an appropriate organic solvent (also loaded with an anti-restenosis drug, such as tacrolimus) are investigated: physicochemical properties, adhesiveness to metallic stent material, and kinetics of drug release in physiological environment are studied.
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Silvestri et al. (2008) studied Cardiovascular application (stent coating). Poly(methylmethacrylate-co-acrylic acid) copolymers loaded with tacrolimus was evaluated on Physicochemical properties, adhesiveness to metallic stent material, and kinetics of drug release. Poly(methylmethacrylate-co-acrylic acid) copolymers were synthesized and investigated for their physicochemical properties, adhesiveness, and drug release kinetics as potential stent coatings.
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