Key result
Myocardial infarction as a first event significantly increased the risk of subsequent cardiovascular death (HR 4.5, P<0.0001), whereas coronary revascularization did not.
Why the study?
Do myocardial infarction and coronary revascularization carry similar prognostic implications for subsequent cardiovascular events in hypertensive patients with LVH?
Cohort (n=9,113)
Yes
Do myocardial infarction and coronary revascularization carry similar prognostic implications for subsequent cardiovascular events in hypertensive patients with LVH?
Hazard Ratio: 4.5
p-value: p=<0.0001
Myocardial infarction, but not coronary revascularization, as a first cardiovascular event significantly increases the risk of subsequent cardiovascular death, all-cause death, and stroke, suggesting caution when combining them in composite endpoints.
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MI as first event was associated with higher subsequent CV death risk than revascularization; leaves open whether to combine them in composite endpoints.
Cicala et al. (2010) conducted a cohort in Hypertension with left ventricular hypertrophy (n=9,113). Myocardial infarction as first event vs. Coronary revascularization as first event was evaluated on Cardiovascular death (HR 4.5, p=<0.0001). Myocardial infarction as a first event significantly increased the risk of subsequent cardiovascular death (HR 4.5, P<0.0001), whereas coronary revascularization did not.
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