Key result
Prompt, aggressive blood pressure lowering using combination therapy with a calcium channel blocker and a renin-angiotensin system inhibitor is an effective strategy for high-risk patients.
Why the study?
Does prompt, aggressive blood pressure lowering with multiple-drug therapy prevent cardiovascular disease progression in high-risk patients with hypertension?
Population
High-risk patients with hypertension, including those with stage 2 hypertension, black patients, and…
Design
Review
Authors
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May support early dual therapy in high-risk hypertension; leaves open randomized confirmation of outcomes.
Does prompt, aggressive blood pressure lowering with multiple-drug therapy prevent cardiovascular disease progression in high-risk patients with hypertension?
Early use of multiple-drug antihypertensive therapy, particularly a calcium channel blocker combined with a renin-angiotensin system inhibitor, is crucial for preventing cardiovascular disease progression in high-risk patients.
Jamerson et al. (2008) conducted a review in Hypertension in high-risk populations. Prompt, aggressive blood pressure lowering (e.g., calcium channel blocker and renin-angiotensin system inhibitor) was evaluated. Prompt, aggressive blood pressure lowering using combination therapy with a calcium channel blocker and a renin-angiotensin system inhibitor is an effective strategy for high-risk patients.
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