Key result
Congestive heart failure was associated with an absence of high-frequency heartbeat chaos and the emergence of transient chaos compared to healthy young and elderly subjects.
Population
Healthy subjects (young and elderly) and patients with congestive heart failure (CHF)
Comparison
Noise titration assay of running short-segment… vs Comparison between healthy young subjects…
Design
Cross-sectional
Authors
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Heartbeat chaos metrics may aid heart failure phenotyping; hypothesis-generating and should not yet change practice.
Cross-Sectional (n=43)
A novel noise titration assay demonstrates that healthy heart rate variability is characterized by circadian-dependent chaos which is preserved in aging but lost in heart failure.
Wu et al. (2009) conducted a cross-sectional in Congestive Heart Failure (n=43). Congestive heart failure and aging vs. Healthy young subjects was evaluated on Heartbeat chaos level measured by noise titration (Detection Rate and Noise Limit). Congestive heart failure was associated with an absence of high-frequency heartbeat chaos and the emergence of transient chaos compared to healthy young and elderly subjects.
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