Why the study?
Does sympathetic nerve stimulation and administration of NA or NPY affect splenic blood flow and capacitance function in pigs and dogs?
Population
Pig and dog spleens (in vivo preparation with intact vascular perfusion)
Comparison
Sympathetic nerve stimulation, reserpine… vs Controls (baseline or pre-reserpine treatment)
Design
Preclinical
Authors
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No immediate clinical translation from porcine and canine data; leaves open NPY mediation of splenic vasoconstriction for translational research.
Does sympathetic nerve stimulation and administration of NA or NPY affect splenic blood flow and capacitance function in pigs and dogs?
Noradrenaline mediates splenic arterial vasoconstriction and capacitance responses in pigs and dogs, while neuropeptide Y may mediate non-adrenergic vasoconstriction in pigs.
Modin et al. (1993) studied this question.
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