January 1, 1989Acta Physiologica Scandinavica

Sympathetic vascular control of the pig nasal mucosa (III): co‐release of noradrenaline and neuropeptide Y

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Population

Pentobarbital anaesthetized pigs

Comparison

Sympathetic nerve stimulation with various… vs Control conditions without pretreatment

Design

Preclinical

Authors

JLJ S LacroixUniversity of Geneva PSPär StjärneKarolinska University Hospital AÄA. ÄnggårdKarolinska University Hospital

Discussion

Member takes

Implication

Does not support clinical changes in nasal disorders; extends in vivo evidence for prejunctional alpha-adrenoceptor regulation of NA/NPY co-release.

Structured PICO

Population

Pentobarbital anaesthetized pigs

Intervention

Sympathetic nerve stimulation with various pharmacological pretreatments (reserpine, phenoxybenzamine, desipramine, mATP)

Comparator

Control conditions without pretreatment

Outcome

Overflows of noradrenaline (NA) and neuropeptide Y like immunoreactivity (NPY-LI) and vascular responsessurrogate

The study demonstrates that sympathetic nerve stimulation in the pig nasal mucosa causes co-release of noradrenaline and neuropeptide Y, regulated by prejunctional alpha-adrenoceptors.

Cite This Study

Lacroix et al. (1989) studied this question.

synapsesocial.com/papers/6a854b60e54a638bbf3d95dc https://doi.org/10.1111/j.1748-1716.1989.tb08546.x

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Implication

Does not support clinical changes in nasal disorders; extends in vivo evidence for prejunctional alpha-adrenoceptor regulation of NA/NPY co-release.

Sympathetic vascular control of the pig nasal mucosa (III): co‐release of noradrenaline and neuropeptide Y

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Sympathetic vascular control of the pig nasal mucosa (III): co‐release of noradrenaline and neuropeptide Y

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider