Why the study?
Do losartan and its metabolite E3174 modify cardiac delayed rectifier K+ currents in ventricular myocytes?
Population
Guinea pig ventricular myocytes and cells expressing hKv1.5 and HERG channels
Design
Preclinical
Authors
Loading...
May affect repolarization at therapeutic concentrations in animals; leaves open human relevance and arrhythmia risk.
Do losartan and its metabolite E3174 modify cardiac delayed rectifier K+ currents in ventricular myocytes?
At therapeutic concentrations, losartan and its metabolite E3174 modify cardiac delayed rectifier potassium currents, which may affect cardiac repolarization.
Caballero et al. (2000) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: