January 1, 2001Hypertension ResearchOpen Access

Acute Effects of E-3174, a Human Active Metabolite of Losartan, on the Cardiovascular System in Tachycardia-Induced Canine Heart Failure.

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Why the study?

Does acute intravenous administration of E-3174 improve hemodynamic functions in a canine model of tachycardia-induced heart failure?

Population

Dogs with severe heart failure established by rapid pacing of the right ventricle for 4 weeks.

Comparison

Acute intravenous administration of E-3174 vs Acute intravenous administration of losartan and…

Design

Preclinical

Follow-up

acute

Authors

JSJun SuzukiYamagata University HOHisashi OhtaHokkaido University KHK. HanadaKyushu University

Discussion

Member takes

Implication

Acute E-3174 improves hemodynamics in canine HF; leaves open translation to patients.

Structured PICO

Does acute intravenous administration of E-3174 improve hemodynamic functions in a canine model of tachycardia-induced heart failure?

Population

Dogs with severe heart failure established by rapid pacing of the right ventricle (250-270 beats/min) for 4 weeks.

Intervention

Acute intravenous administration of E-3174 (0.3 and 1 mg/kg)

Comparator

Acute intravenous administration of losartan (1 mg/kg) and enalapril (0.3 and 1 mg/kg)

Outcome

Changes in cardiovascular and hemodynamic functions (pulmonary artery pressure, pulmonary capillary wedge pressure, mean arterial pressure, stroke volume, peripheral resistance, fractional shortening)surrogate

In a canine model of heart failure, acute AT1 receptor blockade with E-3174 reduced pre- and after-load and increased stroke volume, with effects comparable to enalapril and stronger than losartan.

Cite This Study

Suzuki et al. (2001) studied this question.

synapsesocial.com/papers/6a7cf6eac25c3f1308a1e6ca https://doi.org/10.1291/hypres.24.65

Topics

Heart failure HFrEF treatment Echocardiography

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