Key result
Isoproterenol-induced subendocardial damage in mice impaired global peak longitudinal strain (-12.5% vs -15.6%; P<0.001) and shifted subepicardial helix angle compared to saline.
Why the study?
Subendocardial damage is an early manifestation of hypertension present in asymptomatic states, but its impact on myocardial microstructure and function needed investigation to identify early diagnostic markers.
Does isoproterenol-induced subendocardial damage alter myocardial microstructure and function in mice?
Population
38 mice
Comparison
Isoproterenol injection vs saline control
Design
Animal experimental study
Authors
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Supports mechanistic role of subendocardial damage in strain impairment; leaves open relevance to human hypertension.
Does isoproterenol-induced subendocardial damage alter myocardial microstructure and function in mice?
Absolute Event Rate: -12.5% vs -15.6%
p-value: p=<0.001
Circumscribed subendocardial damage causes impaired longitudinal strain and microstructural remodeling, which may serve as early diagnostic markers for cardiac damage.
Beyhoff et al. (2019) studied Isolated subendocardial damage (n=38). Isoproterenol vs. Saline was evaluated on Global peak longitudinal strain (LS) (p=<0.001). Isoproterenol-induced subendocardial damage in mice impaired global peak longitudinal strain (-12.5% vs -15.6%; P<0.001) and shifted subepicardial helix angle compared to saline.
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