Key result
Abnormal myocardial flow reserve and global longitudinal strain linked to ~221% higher HF hospitalization risk.
Why the study?
Hypertension is a well-established heart failure risk factor, and the authors aimed to use myocardial flow reserve and global longitudinal strain to refine hypertensive heart failure risk assessment.
Does the combination of abnormal MFR and GLS predict heart failure hospitalization in patients undergoing stress PET-CT without reduced LVEF or flow-limiting CAD?
Population
194 consecutive patients undergoing stress PET-CT and echocardiography without LVEF <40% or flow-limiting CAD
Comparison
Abnormal vs normal MFR and GLS across LV remodelling patterns
Design
Cohort study
Follow-up
Median 8.75 (Q1-3 4.56-10.04) years
Authors
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May enhance HF risk stratification in hypertensive patients without reduced LVEF; hypothesis-generating and requires prospective validation before clinical adoption.
Cohort (n=194)
Does the combination of abnormal MFR and GLS predict heart failure hospitalization in patients undergoing stress PET-CT without reduced LVEF or flow-limiting CAD?
Effect estimate: adjusted HR 3.21 (95% CI 1.09-9.45)
p-value: p=0.034
The combination of abnormal myocardial flow reserve and global longitudinal strain identifies patients at significantly higher risk for heart failure hospitalization, refining risk assessment in patients without reduced LVEF or obstructive CAD.
Zhou et al. (2020) conducted a cohort in Hypertension (n=194). Abnormal MFR and GLS vs. Normal MFR and GLS was evaluated on Heart failure hospitalization (adjusted HR 3.21, 95% CI 1.09-9.45, p=0.034). Abnormal myocardial flow reserve and global longitudinal strain increased the risk of heart failure hospitalization compared to normal parameters (adjusted HR 3.21; 95% CI 1.09-9.45; P=0.034).
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