Key result
In elderly Japanese men with high hemoglobin concentrations, height was significantly inversely associated with platelet count (β = -0.22, p = 0.019), suggesting short stature is linked to stronger vascular remodeling activation.
Cross-Sectional (n=219)
Effect estimate: β = -0.22
p-value: p=0.019
In elderly Japanese men with high hemoglobin levels, shorter stature is associated with higher platelet counts, increased CIMT, and more circulating CD34-positive cells, suggesting greater activation of vascular remodeling.
Should not yet change vascular risk assessment in short elderly men; leaves open whether height influences platelet-mediated remodeling.
// Yuji Shimizu 1, 2 , Shimpei Sato 1 , Jun Koyamatsu 3 , Hirotomo Yamanashi 3 , Mako Nagayoshi 1 , Koichiro Kadota 1 , Shin-Ya Kawashiri 1 and Takahiro Maeda 1, 3 1 Department of Community Medicine, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan 2 Department of Cardiovascular Disease Prevention, Osaka Center for Cancer and Cardiovascular Disease Prevention, Osaka, Japan 3 Department of Island and Community Medicine, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan Correspondence to: Yuji Shimizu, email: shimizuyuji@nagasaki-u.ac.jp Keywords: platelets; height; vascular remodeling; CIMT; CD34-positive cell; Gerotarget Received: September 29, 2017 Accepted: October 30, 2017 Published: December 23, 2017 ABSTRACT Height is reported to be inversely associated with cardiovascular disease. And platelets play an important role in vascular remodeling by supporting CD34-positive cells. To clarify the association between height and platelet, we conducted a cross-sectional study of 219 elderly Japanese men. Since hemoglobin concentration is influenced by vascular remodeling activity, an analysis stratified by hemoglobin level was performed. An inverse association was seen between height and platelet count in subjects with a high hemoglobin concentration (≥ 14.5 g/dL), but not in subjects with a low hemoglobin concentration (< 14.5 g/dL). The standardized parameter estimates (β) were β = −0.22, p = 0.019 for subjects with high hemoglobin, and β = −0.01, p = 0.931 for subjects with low hemoglobin. We also found a positive association between platelets and carotid intima media thickness (CIMT) and circulating CD34-positive cells in subjects with high hemoglobin (partial correlation coefficient (r) = 0.21, p = 0.037 and r = 0.40, p =< 0.001), but not in subjects with low hemoglobin ( r = 0.04, p = 0.710 and r = 0.06, p = 0.544). In subjects with a high hemoglobin concentration, platelets were inversely associated with height, and positively associated with CIMT and circulating CD34-positive cells. These results indicate that subjects with a short stature activate vascular remodeling to a much greater extent than subjects with a tall stature.
No takes yet. Share an insight, caveat, or question.
Shimizu et al. (2017) conducted a cross-sectional in Vascular remodeling (n=219). Height was evaluated on Association between height and platelet count in subjects with high hemoglobin concentration (≥ 14.5 g/dL) (β = -0.22, p=0.019). In elderly Japanese men with high hemoglobin concentrations, height was significantly inversely associated with platelet count (β = -0.22, p = 0.019), suggesting short stature is linked to stronger vascular remodeling activation.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: