Key result
Greater height is linked to ~29% lower carotid atherosclerosis odds in overweight men.
Why the study?
Evidence is limited for the association between adult height and risk of atherosclerosis, particularly in relation to BMI status.
Is adult height associated with the risk of carotid atherosclerosis, and does BMI modify this association?
Cross-Sectional (n=1,337)
Is adult height associated with the risk of carotid atherosclerosis, and does BMI modify this association?
Odds Ratio: 0.71 (95% CI 0.54–0.94)
Height is inversely associated with carotid atherosclerosis specifically in overweight men, suggesting an interaction between height, adiposity, and atherosclerotic risk.
Height inversely associated with carotid atherosclerosis only in overweight men; leaves open whether BMI modifies this link in other groups or warrants risk stratification.
BACKGROUND: Previous studies have reported an inverse association between height and risk of cardiovascular disease. However, evidence is limited for the association between risk of atherosclerosis and height. Further, although the association between atherosclerosis and body mass index (BMI) is reportedly positive, there have been no reports of studies on associations between height and atherosclerosis in relation to BMI. METHODS: We conducted a cross-sectional study of Japanese men aged 30 to 89 years undergoing general health check-ups. RESULTS: Of the 1,337 men, 312 were diagnosed with carotid atherosclerosis (carotid intima-media thickness (CIMT) ≥ 1.1 mm), but no significant association was found between height and carotid atherosclerosis for the entire study group. Stratification by BMI status of those analytical findings disclosed a significant inverse association between height and carotid atherosclerosis among overweight (BMI ≥ 25 kg/m(2)) but not among non-overweight (BMI < 25 kg/m(2)) men. The classical cardiovascular risk factors-adjusted odds ratio (OR) and 95% confidence interval (CI) of carotid atherosclerosis for an increment of one SD (standard deviation) in height (6.70 cm) were 0.71 (0.54 to 0.94) for overweight (BMI ≥ 25 kg/m(2)) and 1.05 (0.87 to 1.27) for non-overweight (BMI < 25 kg/m(2)) men. CONCLUSION: Independent from classical cardiovascular risk factors, height was found to be inversely associated with carotid atherosclerosis for overweight but not for non-overweight men.
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Shimizu et al. (2013) conducted a cross-sectional in Carotid atherosclerosis (n=1,337). Height vs. Lower height was evaluated on Carotid atherosclerosis (CIMT ≥ 1.1 mm) in overweight men (BMI ≥ 25 kg/m2) for a 1 SD increment in height (OR 0.71, 95% CI 0.54 to 0.94). An increment of one standard deviation in height (6.70 cm) was associated with lower odds of carotid atherosclerosis in overweight men (OR 0.71), but not in non-overweight men.
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