Key result
Platelet count positively correlated with circulating CD34-positive cells in non-hypertensive men (β=0.26, p<0.001) and with carotid intima media thickness in hypertensive men (β=0.19, p=0.008).
Why the study?
Does platelet count correlate with markers of vascular repair (carotid intima media thickness and circulating CD34-positive cells) in elderly Japanese men?
Cross-Sectional (n=567)
Does platelet count correlate with markers of vascular repair (carotid intima media thickness and circulating CD34-positive cells) in elderly Japanese men?
Effect estimate: β = 0.26 (CD34, non-hypertensive); β = 0.19 (IMT, hypertensive)
p-value: p=<0.001 and 0.008
Platelet count may serve as an indicator of vascular repair activity, with its relationship to endothelial repair markers and atherosclerosis modified by the presence of hypertension.
Platelet associations with CD34+ cells and carotid IMT in men are hypothesis-generating; prospective studies needed before clinical consideration.
// Yuji Shimizu 1,2 , Shimpei Sato 1 , Jun Koyamatsu 1 , Hirotomo Yamanashi 3 , Mako Nagayoshi 1 , Koichiro Kadota 1 and Takahiro Maeda 1,3 1 Department of Community Medicine, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan 2 Osaka Center for Cancer and Cardiovascular Disease Prevention, Osaka, Japan 3 Department of Island and Community Medicine, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan Correspondence to: Yuji Shimizu, email: // Keywords : platelets, vascular repair, atherosclerosis, hypertension, CD34-positive cell, elderly men, Gerotarget Received : May 24, 2016 Accepted : June 09, 2016 Published : June 22, 2016 Abstract Platelets and circulating CD34-positive cells have been reported to contribute to vascular repair (endothelial repair and developing atherosclerosis). And because hypertension is known to be a strong vascular impairment factors, it should also influence the respective numbers of these factors. To clarify the clinical importance of platelets on vascular repair, we conducted a cross-sectional study of 567 Japanese men aged 60-69 who underwent an annual health check-up between 2013 and 2015. Multiple linear regression analysis of non-hypertensive subjects adjusting for classical cardiovascular risk factors showed that although platelet count did not significantly correlate with carotid intima media thickness (β = -0.05, p = 0.356), it did positively correlate significantly with the natural log of the number of circulating CD34-positive cells (β = 0.26, p < 0.001). In hypertensive subjects, a significant positive correlation was seen between platelets and intima media thickness (β = 0.19, p = 0.008), whereas no significant correlation was seen between platelet count and the natural log of the number of circulating CD34-positive cells (β = 0.11, p = 0.119). Our results indicate that platelet count is an indicator of vascular repair activity (endothelial repair and developing atherosclerosis). Additionally, hypertension might mask the beneficial effects of circulating CD34-positive cells.
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Shimizu et al. (2016) conducted a cross-sectional in Annual health check-up (n=567). Platelet count was evaluated on Carotid intima media thickness and circulating CD34-positive cells (β = 0.26 (CD34, non-hypertensive); β = 0.19 (IMT, hypertensive), p=<0.001 and 0.008). Platelet count positively correlated with circulating CD34-positive cells in non-hypertensive men (β=0.26, p<0.001) and with carotid intima media thickness in hypertensive men (β=0.19, p=0.008).
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