Key result
A higher logarithmic circulating CD34+ cell count was significantly associated with active arterial wall thickening in elderly men without hypertension (OR 1.83), but not in those with hypertension.
Why the study?
No prospective study had clarified the association of circulating CD34+ cells with active arterial wall thickening.
Cohort (n=363)
Odds Ratio: 1.83 (95% CI 1.19–2.84)
p-value: p=0.009
Higher circulating CD34+ cell counts are positively associated with active arterial wall thickening in elderly men without hypertension, suggesting a role in age-related endothelial repair.
Should not change practice; hypothesis-generating for CD34+ cells in normotensive elderly vascular remodeling.
Age-related physical changes, such as low-grade inflammation and increased oxidative stress, induce endothelial repair and cause active arterial wall thickening by stimulating the production of CD34+ cells (the principal mediators of atherosclerosis). Despite this, aggressive endothelial repair (progressing atherosclerosis) might cause a wasting reduction in CD34+ cells, which could result in a lower capacity of endothelial repair and hypertension. As yet, no prospective study has clarified the association of circulating CD34+ cells with active arterial wall thickening. We conducted a prospective study of 363 men aged 60-69 years who participated in a general health check-up at least twice from 2014-2017. The circulating CD34+ cell count was significantly positively associated with active arterial wall thickening among subjects without hypertension (n = 236), but not among subjects with hypertension (n = 127). The fully adjusted odds ratios (ORs) of active arterial wall thickening for the logarithmic circulating CD34+ cell count were 1.83 (1.19, 2.84) and 0.69 (0.36, 1.32) for subjects without and with hypertension, respectively. Circulating CD34+ cells are positively associated with active arterial wall thickening in subjects without hypertension. This study demonstrates a means to clarify the mechanisms of endothelial repair in elderly subjects.
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Shimizu et al. (2020) conducted a cohort in Active arterial wall thickening (n=363). Logarithmic circulating CD34+ cell count vs. Lower CD34+ cell count was evaluated on Active arterial wall thickening (CIMT increment ≥ 0.01 mm/year) (OR 1.83, 95% CI 1.19, 2.84, p=0.009). A higher logarithmic circulating CD34+ cell count was significantly associated with active arterial wall thickening in elderly men without hypertension (OR 1.83), but not in those with hypertension.
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