Key result
Opioid blockade with 50 mg naltrexone increased salivary cortisol levels and pain ratings compared to placebo, with effects on pain being more pronounced in women.
Why the study?
Does opioid blockade with naltrexone alter adrenocortical and nociceptive responses in hypertension-prone men and women compared to placebo?
Population
99 men and women, including individuals at high risk for hypertension and low-risk individuals
Comparison
Naltrexone 50 mg vs Placebo
Design
RCT, counterbalanced design, double-blind
Follow-up
during two study sessions
Authors
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Opioid blockade heightens cortisol and pain reactivity in hypertension-prone adults; extends evidence linking hypoalgesia to hypertension risk with sex-specific patterns.
RCT (n=99)
Double-blind
counterbalanced
Does opioid blockade with naltrexone alter adrenocortical and nociceptive responses in hypertension-prone men and women compared to placebo?
Opioid blockade with naltrexone increases cortisol and pain responses, revealing that hypoalgesia may serve as a marker of hypertension risk in men.
Al’Absi et al. (2006) conducted an RCT in Hypertension risk (n=99). Naltrexone vs. Placebo was evaluated on Adrenocortical and nociceptive responses (salivary cortisol levels, pain ratings, MPQ scores, pain threshold and tolerance). Opioid blockade with 50 mg naltrexone increased salivary cortisol levels and pain ratings compared to placebo, with effects on pain being more pronounced in women.
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