What question did this study set out to answer?

To determine whether altered baroreflex function mediates the abnormal pressor response to naloxone during stress in individuals at risk for developing essential hypertension.

January 1, 1988Psychosomatic Medicine

Opioid dysfunction and risk for hypertension: naloxone and blood pressure responses during different types of stress.

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Why the study?

Does naloxone alter blood pressure responses during psychological and orthostatic stress differently in persons with high versus low casual blood pressure?

Population

Persons with high and low casual blood pressure (at risk for hypertension development)

Design

Other

Authors

JMJames A. McCubbinUniversity of North Carolina at Chapel Hill RSRichard S. SurwitSprint (United States)RWRedford B. WilliamsPreventive Cardiology

Discussion

Member takes

Implication

Supports opioid lesion in central autonomic control independent of baroreflex in prehypertension; hypothesis-generating and should not yet change practice.

Key Points

To determine whether altered baroreflex function mediates the abnormal pressor response to naloxone during stress in individuals at risk for developing essential hypertension.
Evaluated physiological reactions in subjects categorized by high versus low casual blood pressure.
Administered the opioid antagonist naloxone and compared blood pressure responses during psychological stress against responses during orthostatic stress.
Abnormal opioidergic regulation of systolic blood pressure during psychological stress occurred independently of baroreflex function changes.
Individuals at risk for hypertension showed evidence of an opioid peptide defect localized either at the adrenal medullae or in central autonomic control regions parallel or rostral to baroreflex circuits.

Structured PICO

Does naloxone alter blood pressure responses during psychological and orthostatic stress differently in persons with high versus low casual blood pressure?

Population

Persons with high and low casual blood pressure (at risk for hypertension development)

Intervention

Naloxone

Outcome

Blood pressure responses to psychological stress compared with orthostatic stresssurrogate

Persons at risk for hypertension may have an opioid peptide lesion affecting central autonomic control or adrenal medullae, independent of baroreflex function.

Cite This Study

McCubbin et al. (1988) studied this question.

synapsesocial.com/papers/6a8802e0b0d802598bf4cd87 https://doi.org/10.1097/00006842-198801000-00002

Topics

Hypertension management

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Implication

Supports opioid lesion in central autonomic control independent of baroreflex in prehypertension; hypothesis-generating and should not yet change practice.

Opioid dysfunction and risk for hypertension: naloxone and blood pressure responses during different types of stress.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Opioid dysfunction and risk for hypertension: naloxone and blood pressure responses during different types of stress.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider