Key result
Fine-needle aspiration cytology of a rare renal epithelioid angiosarcoma in an 83-year-old male revealed pleomorphic epithelioid cells positive for vimentin, CD31, CD34, Factor VIII, and CD10.
Case Report (n=1)
Fine-needle aspiration cytology combined with specific immunohistochemical markers can aid in the challenging diagnosis of rare epithelioid angiosarcomas of the kidney.
FNA with IHC may aid diagnosis of rare renal epithelioid angiosarcoma; leaves open validation in larger series.
Epithelioid angiosarcomas (EAS) of kidney are rare and aggressive tumors with noncharacteristic imaging features that overlap with those of inflammatory conditions and renal cell carcinoma (RCC). We report the fine-needle aspiration (FNA) cytology findings of a case of EAS that involved the left kidney of an 83-year-old male. The smears and cell block sections showed pleomorphic epithelioid cells with ample cytoplasm, eccentric nuclei, occasional cytoplasmic hyaline globules, and rare intracytoplasmic lumina. Immunohistochemical stains performed on cellblock sections showed that the tumor cells were positive for vimentin, CD31, CD34, Factor VIII, and CD10, but showed no staining for cytokeratins AE1/AE3 and 8/18, HMB45, CD45, smooth muscle actin, and S100. The morphological and immunohistochemical distinction between EAS, primary tumors of the kidney, and other epithelioid and rhabdoid neoplasms is discussed.
No takes yet. Share an insight, caveat, or question.
Singh et al. (2011) conducted a case report in Epithelioid angiosarcoma of the kidney (n=1). Fine-needle aspiration (FNA) cytology was evaluated on Cytological and immunohistochemical findings. Fine-needle aspiration cytology of a rare renal epithelioid angiosarcoma in an 83-year-old male revealed pleomorphic epithelioid cells positive for vimentin, CD31, CD34, Factor VIII, and CD10.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: