Key result
Epithelioid angiosarcoma was successfully diagnosed from a lung resection sample using a combination of gross findings, imprint cytology, and immunocytochemistry.
Why the study?
Epithelioid angiosarcoma is difficult to diagnose due to its morphological resemblance to carcinoma and shared expression of epithelial markers.
Case Report (n=1)
Imprint cytology combined with immunocytochemistry can facilitate prompt diagnosis of epithelioid angiosarcoma, which is particularly useful when obtaining tissue samples is challenging.
Hypothesis-generating for rare sarcoma diagnosis with limited tissue; prospective validation needed before adoption.
BACKGROUND: Angiosarcoma, a very rare malignant tumor constituting 2%-4% of soft tissue sarcomas, manifest in diverse organs including skin, soft tissues, and bones. Histologically, angiosarcoma presents a wide range of morphologies, with epithelioid angiosarcoma (EAS) resemblance to carcinoma. The difficulty arises from the shared epithelial-like morphology and expression of epithelial markers in immunohistochemistry. CASE: This study reports a case where EAS diagnosis was achieved through a combination of gross findings in a lung resection sample, imprint cytology, and immunocytochemistry. Imprint cytology revealed clusters of epithelioid cells, while immunocytochemistry showed positive results for CD31, ERG, Fli-1, and AE1/AE3, proving instrumental in diagnosing EAS. The described immunocytochemical protocol facilitates prompt diagnosis exclusively through cytology samples. CONCLUSION: This report emphasizes the potential for diagnosing EAS using cytological specimens, which is especially useful in cases where obtaining tissue samples proves challenging.
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Mori et al. (2024) conducted a case report in Epithelioid angiosarcoma (n=1). Imprint cytology and immunocytochemistry was evaluated on Diagnosis of epithelioid angiosarcoma. Epithelioid angiosarcoma was successfully diagnosed from a lung resection sample using a combination of gross findings, imprint cytology, and immunocytochemistry.
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