Population
Mice with targeted deletion of the cardiac isoform of troponin I
Design
Preclinical
Follow-up
18 days after birth
Authors
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Confirms cTnI essentiality for murine cardiac survival; leaves open translation to human troponinopathies or therapies.
Deletion of cardiac troponin I in mice is lethal by day 18 due to acute heart failure, demonstrating its absolute requirement for normal cardiac mechanics and survival.
Huang et al. (1999) studied this question.
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