Cation regulation of anion current activated by cell swelling in two types of human epithelial cancer cells.
Population
Human epithelial cancer cell lines H69AR and HeLa S5
Comparison
Hyposmotic stress and manipulation of external… vs Standard bath solutions with inorganic cations
Design
Preclinical
Authors
Discussion
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Member takes
Implication
External Mg2+ may regulate volume-activated Cl- currents in cancer cells; leaves open its physiological role and clinical relevance.
Structured PICO
P
Population
Human epithelial cancer cell lines H69AR and HeLa S5
I
Intervention
Hyposmotic stress and manipulation of external cations (replacement with N-methyl-D-glucamine [NMDG], re-addition of Mg2+ or other Group II metals)
C
Comparator
Standard bath solutions with inorganic cations
O
Outcome
Cl- current activation, relaxation, and steady-state current levelssurrogate
External Group II metals, particularly Mg2+, regulate the relaxation of volume-activated Cl- currents in human epithelial cancer cells.
Cite This Study
Anderson et al. (1995) studied this question.