Key result
Severe uncomplicated obesity was associated with greater left ventricular mass than normal weight (P<0.01), but changes were largely adapted and appropriate for body size.
Why the study?
Does severe uncomplicated obesity cause pathological changes in left ventricular structure and function compared to normal weight?
Population
110 subjects: 55 uncomplicated severely obese patients and 55 age-matched normal-weight controls.
Comparison
Severe uncomplicated obesity vs Age-matched normal-weight subjects
Design
Cross-sectional
Authors
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Supports adaptive rather than pathological LV remodeling in severe uncomplicated obesity; hypothesis-generating for longitudinal progression studies.
Cross-Sectional (n=110)
Does severe uncomplicated obesity cause pathological changes in left ventricular structure and function compared to normal weight?
p-value: p=<0.01
Uncomplicated severe obesity is associated with adapted and appropriate changes in cardiac structure and hyperdynamic systolic function, rather than pathological remodeling.
Iacobellis et al. (2004) conducted a cross-sectional in Severe uncomplicated obesity (n=110). Severe uncomplicated obesity vs. Normal-weight subjects was evaluated on Left ventricular mass and indexed left ventricular mass (p=<0.01). Severe uncomplicated obesity was associated with greater left ventricular mass than normal weight (P<0.01), but changes were largely adapted and appropriate for body size.
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