Key result
Asymptomatic obesity is linked to ~32% thicker LV walls and diastolic dysfunction versus normal weight.
Why the study?
Obesity is a major modern health issue, and its early effects on ventricular function warrant assessment via conventional 2D echocardiography and echocardiogram.
Does obesity alter echocardiographic measures of ventricular function in asymptomatic subjects compared to normal-weight individuals?
Cross-Sectional (n=100)
No
Does obesity alter echocardiographic measures of ventricular function in asymptomatic subjects compared to normal-weight individuals?
Asymptomatic obesity is associated with early subclinical structural and functional cardiac changes, including increased left ventricular wall thickness and diastolic dysfunction, detectable by echocardiography.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for subclinical LV changes in asymptomatic obesity; prospective studies needed to assess clinical impact.
Background: Obesity constitutes a major health issue in the modern world. The purpose of this prospective study was to assess the effect of obesity on ventricular function by conventional 2D echocardiography and echocardiogram for assessment of early cardiac changes.Methods: In the present study, 50 asymptomatic obese subjects having BMI >30 were compared with 50 normal individuals having BMI in the range 20-24.9 to assess cardiac performance. The study was conducted over a period of 2 years, from 2009 to 2011.Results: There were 20(40%) males and 30(60%) females in both the groups. The ejection fraction was not significantly affected in obese subjects (60.86±1.34%) than normal individual (60.42±1.18%) which was found to be statistically not significant. So, in this study systolic function was not affected. The thickness of left ventricle was significantly increased in obese subjects (1.016±0.113 cm) than normal individual (0.77+0.073 cm) which was found to be statistically significant.Conclusions: The current study revealed increased wall thickness and mass of Left Ventricle (LV), significantly increased risk of LV diastolic dysfunction, evidence of Left Atrial (LA) enlargement associated with diastolic dysfunction, evidence of subclinical LV systolic dysfunction and Right Ventricular (RV) dysfunction among obese subjects in comparison with normal individuals.
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Wanjari et al. (2019) conducted a cross-sectional in Obesity (n=100). Obesity (BMI > 30) vs. Normal BMI (18.5 to 25 kg/m2) was evaluated on Thickness of left ventricle (cm) (p=<0.0001). Asymptomatic obesity was associated with increased left ventricular wall thickness and evidence of diastolic dysfunction compared to normal-weight individuals.
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