Key result
Asymptomatic obesity is linked to ~32% thicker LV walls and diastolic dysfunction versus normal weight.
Why the study?
Obesity is a major modern health issue, and its early effects on ventricular function warrant assessment via conventional 2D echocardiography and echocardiogram.
Does obesity alter echocardiographic measures of ventricular function in asymptomatic subjects compared to normal-weight individuals?
Population
50 asymptomatic obese subjects (BMI >30) and 50 normal individuals (BMI 20-24.9)
Comparison
Asymptomatic obese subjects vs normal individuals
Design
Prospective study
Authors
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Hypothesis-generating for subclinical LV changes in asymptomatic obesity; prospective studies needed to assess clinical impact.
Cross-Sectional (n=100)
No
Does obesity alter echocardiographic measures of ventricular function in asymptomatic subjects compared to normal-weight individuals?
Absolute Event Rate: 1.016% vs 0.77%
p-value: p=<0.0001
Asymptomatic obesity is associated with early subclinical structural and functional cardiac changes, including increased left ventricular wall thickness and diastolic dysfunction, detectable by echocardiography.
Wanjari et al. (2019) conducted a cross-sectional in Obesity (n=100). Obesity (BMI > 30) vs. Normal BMI (18.5 to 25 kg/m2) was evaluated on Thickness of left ventricle (cm) (p=<0.0001). Asymptomatic obesity was associated with significantly increased left ventricular wall thickness (1.016 cm vs 0.77 cm, p<0.0001) and evidence of diastolic dysfunction compared to normal-weight individuals.
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