Key result
Overweight and obesity in patients with chronic LV volume overload were associated with greater LV mass (208.4g vs 177.7g; p<0.0001) and lower myocardial contractility (91.7% vs 95.6%; p=0.0058).
Why the study?
Does overweight and obesity impact left ventricular mass and systolic function in patients with chronic LV volume overload due to degenerative aortic regurgitation?
Population
885 subjects with degenerative aortic regurgitation (chronic left ventricular volume overload)
Comparison
Overweight and obesity vs Normal-weight patients
Design
Cross-sectional
Authors
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Should not yet change AR management; hypothesis-generating for obesity's role in LV remodeling.
Observational (n=885)
Does overweight and obesity impact left ventricular mass and systolic function in patients with chronic LV volume overload due to degenerative aortic regurgitation?
Absolute Event Rate: 208.4% vs 177.7%
p-value: p=<0.0001
Overweight and obesity are associated with increased left ventricular hypertrophy and impaired myocardial contractility in patients with chronic LV volume overload from aortic regurgitation.
Ballo et al. (2007) conducted an observational in Chronic left ventricular volume overload due to degenerative aortic regurgitation (n=885). Overweight and obesity vs. Normal-weight was evaluated on Left ventricular (LV) mass (p=<0.0001). Overweight and obesity in patients with chronic LV volume overload were associated with greater LV mass (208.4g vs 177.7g; p<0.0001) and lower myocardial contractility (91.7% vs 95.6%; p=0.0058).
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