Pharmacological targeting of KCNQ-encoded Kv7 channels presents a broad therapeutic appeal due to their physiological impact and involvement in hereditary disorders.
Pharmacological targeting of KCNQ-encoded Kv7 potassium channels presents a broad therapeutic appeal due to their physiological impact and role in hereditary disorders.
K v 7 channels are voltage-gated potassium channels encoded by KCNQ genes that have a considerable physiological impact in many cell types. This reliance upon K v 7 channels for normal cellular function, as well as the existence of hereditary disorders caused by mutations to KCNQ genes, means that pharmacological targeting of these channels has broad appeal. Consequently, a plethora of chemical entities that modulate K v 7 channel activity have been developed. Moreover, K v 7 channels are influenced by many disparate intracellular mediators and trafficking processes, making upstream targeting an appealing prospect for therapeutic development. This review covers the main characteristics of these multifunctional and versatile channels with the aim of providing insight into the therapeutic value of targeting these channels.
Barrese et al. (Mon,) conducted a review in Hereditary disorders caused by mutations to KCNQ genes. Pharmacological targeting of Kv7 channels was evaluated. Pharmacological targeting of KCNQ-encoded Kv7 channels presents a broad therapeutic appeal due to their physiological impact and involvement in hereditary disorders.