Key result
Targeting Kv7 channels represents an emerging therapeutic strategy against epilepsy due to their pronounced control over neuronal excitability.
Kv7 channels represent an emerging therapeutic target for epilepsy and potentially other excitability disorders like cardiac arrhythmias.
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Kv7 targeting merits investigation for epilepsy and arrhythmias; leaves open clinical utility pending targeted trials.
Kv channels, the voltage-gated potassium channels, are encoded by KCN gene family. Kv channels are important in maintaining the resting membrane potential and spiking threshold, deciding the firing frequency and nerve hyperexcitability, and inducing after hyperpolarization after burst firing. In this family, Kv7 is a special one for it is activated at subthreshold potentials. Because of its specific characteristics, Kv7 channels show pronounced control over the excitability of neurons and often inhibit neuronal excitability. Moreover, it is also documented that mutations of Kv7 channels are associated with the occurrence of epilepsy, deafness and cardiac arrhythmia. In this review, we discussed the characteristics and functions of Kv channels especially the Kv7 channels, which determined their targeting role in treatment against epilepsy.
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Diao et al. (2017) conducted a review in epilepsy. Kv7 channels targeted therapy was evaluated. Targeting Kv7 channels represents an emerging therapeutic strategy against epilepsy due to their pronounced control over neuronal excitability.
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