Key result
Targeting neuronal Kv7.2/3 channels offers diverse molecular scaffolds to treat epilepsy and hyperexcitability diseases.
Population
Neuronal Kv7.2/3 channels, with a focus on their involvement in epilepsy
Design
Review
Authors
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May inform antiepileptic drug discovery; leaves open clinical validation of specific Kv7.2/3 scaffolds.
This review highlights the structural and functional heterogeneity of Kv7.2/3 channel modulators and their potential therapeutic applications, particularly in epilepsy.
Miceli et al. (2017) conducted a review in Epilepsy and other hyperexcitability diseases. Drugs acting on neuronally-expressed Kv7.2/3 channels was evaluated. Pharmacological targeting of neuronally-expressed Kv7.2/3 channels offers diverse molecular scaffolds for developing modulators to treat epilepsy and other hyperexcitability diseases.
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