Key result
Kv7 channel openers show therapeutic potential for diseases driven by dopaminergic and serotonergic overactivity.
Why the study?
The influence of neuronal Kv7 channels on dopaminergic and serotonergic neurotransmission and their therapeutic potential in related diseases is not fully understood.
Comparison
Kv7 channel openers vs no intervention
Design
Review
Authors
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Hypothesis-generating for Kv7 openers in schizophrenia and anxiety; leaves open need for clinical trials.
Kv7 channel openers represent a potential novel therapeutic approach for conditions involving dopaminergic or serotonergic overactivity, such as schizophrenia, drug abuse, and anxiety.
Hansen et al. (2008) conducted a review in Overactivity of dopaminergic and serotonergic neurotransmission (e.g., schizophrenia, drug abuse, anxiety). Kv7 channel openers was evaluated. Kv7 channel openers may have therapeutic value in treating disease states characterized by overactivity of dopaminergic and serotonergic neurotransmission, such as schizophrenia, drug abuse, and anxiety.
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