What question did this study set out to answer?

To evaluate renal sympathetic nerve activity by measuring the renal venous overflow of noradrenaline, dopamine, and renin in humans during reflex activation.

September 1, 1988Acta Physiologica Scandinavica

Reflex activation of renal nerves in humans: differential effects on noradrenaline, dopamine and renin overflow to renal venous plasma

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Why the study?

Do isometric handgrip exercise and dihydralazine alter renal sympathetic nerve activity, dopamine overflow, and renin release in healthy volunteers?

Key Points

To evaluate renal sympathetic nerve activity by measuring the renal venous overflow of noradrenaline, dopamine, and renin in humans during reflex activation.
Measured renal venous blood flow and catecholamine extraction using a thermodilution technique in 10 healthy volunteers.
Evaluated reflex renal sympathetic nerve responses during isometric handgrip exercise and dihydralazine-induced vasodilation.
Isometric handgrip exercise increased renal vascular resistance by 20% and noradrenaline overflow by 123%, decreasing the dopamine-to-noradrenaline overflow ratio from 0.15 to 0.06 (P < 0.01) without altering dopamine or renin release.
Dihydralazine-induced vasodilation increased noradrenaline overflow by 63% (P < 0.05), dopamine overflow by 107 ± 59%, and renin release by 377% (P < 0.001).

Structured PICO

Do isometric handgrip exercise and dihydralazine alter renal sympathetic nerve activity, dopamine overflow, and renin release in healthy volunteers?

Population

10 healthy volunteers

Intervention

Isometric handgrip exercise (IHG) and dihydralazine (HYDR)

Comparator

Rest (baseline)

Outcome

Renal sympathetic nerve activity evaluated by measurements of noradrenaline (NA) and dopamine (DA) overflow to renal venous plasma, and renin releasesurrogate

The dissociation of renal noradrenaline and dopamine responses to different stimuli suggests the human kidney may possess a distinct subset of dopaminergic nerves.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Does not guide clinical practice in healthy subjects; hypothesis-generating for distinct renal dopaminergic nerves.

Cite This Study

Tidgren et al. (1988) studied this question.

synapsesocial.com/papers/6a71c5a8c1a24a6142dbbfb8 https://doi.org/10.1111/j.1748-1716.1988.tb08455.x

View Full Paper

Ask AI

Bookmark

Reflex activation of renal nerves in humans: differential effects on noradrenaline, dopamine and renin overflow to renal venous plasma

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Reflex activation of renal nerves in humans: differential effects on noradrenaline, dopamine and renin overflow to renal venous plasma

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider