Why the study?
Does fosinopril reduce proteinuria in normotensive adult patients with IgA nephropathy?
Population
39 adult patients with biopsy-proven IgA nephropathy, normal blood pressure, normal renal function, and…
Comparison
Fosinopril administered for 4 months in a… vs Placebo administered for 4 months in a…
Design
RCT, Randomly administered in two 4-month sequences separated by a 1-month…
Follow-up
4 months per treatment sequence
Authors
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Supports fosinopril for proteinuria reduction in normotensive IgA nephropathy; extends ACEI renoprotection beyond hypertension.
Does fosinopril reduce proteinuria in normotensive adult patients with IgA nephropathy?
Fosinopril significantly reduces proteinuria in normotensive patients with IgA nephropathy, suggesting a renoprotective effect independent of major blood pressure lowering.
Maschio et al. (1994) studied this question.
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