Key result
Fetuses with congenital heart disease diagnosed between 2000 and 2005 had significantly higher overall survival compared to a historical 1983-1996 cohort (73.9% vs 45.0%, P<0.0001).
Why the study?
Does modern perinatal management (2000-2005) improve survival in fetuses with congenital heart disease compared to a historical cohort (1983-1996)?
Cohort (n=649)
Yes
Does modern perinatal management (2000-2005) improve survival in fetuses with congenital heart disease compared to a historical cohort (1983-1996)?
Absolute Event Rate: 73.9% vs 45%
p-value: p=<0.0001
Survival of fetuses with congenital heart disease significantly improved in the 2000-2005 era compared to 1983-1996, likely due to improved perinatal management and treatment.
No takes yet. Share an insight, caveat, or question.
Supports modern-era perinatal care association with higher fetal CHD survival; extends historical comparisons but leaves causality open for prospective confirmation.
Fesslová et al. (2014) conducted a cohort in congenital heart disease (n=649). Recent era (2000-2005) vs. Previous era (1983-1996) was evaluated on Overall survival (p=<0.0001). Fetuses with congenital heart disease diagnosed between 2000 and 2005 had significantly higher overall survival compared to a historical 1983-1996 cohort (73.9% vs 45.0%, P<0.0001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: