Key result
Among 847 cases with fetal diagnosis of congenital heart disease, 28.9% were terminated; of 602 continuing pregnancies, 11.9% died in utero, 43% died postnatally, and 45% survived.
Population
847 cases with a fetal diagnosis of congenital heart disease, confirmed postnatally or postmortem, with…
Design
Cohort
Follow-up
up to 18 months to 13 years of age
Authors
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Substantial fetal and postnatal loss after CHD diagnosis; hypothesis-generating for prognostic modeling and prospective intervention trials.
Cohort (n=847)
Yes
Fetal diagnosis of complex congenital heart disease is associated with significant fetal and postnatal loss, with associated anomalies and heart failure acting as negative prognostic factors.
Fesslová et al. (1999) conducted a cohort in Congenital heart disease (n=847). Fetal diagnosis of congenital heart disease was evaluated on Evolution and outcome in utero and after birth (termination, in utero death, postnatal death, survival). Among 847 cases with fetal diagnosis of congenital heart disease, 28.9% were terminated; of 602 continuing pregnancies, 11.9% died in utero, 43% died postnatally, and 45% survived.
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