Key result
This review highlights the pathology of pulmonary vascular remodeling in congenital heart disease and issues with stereological approaches to pulmonary vasculature morphometry.
This review provides insights into the morphological and stereological assessment of pulmonary vascular remodeling in congenital heart disease-associated pulmonary arterial hypertension.
Challenges stereological morphometry in pulmonary vascular remodeling; leaves open standardized approaches for congenital heart disease research.
Pulmonary vascular remodeling is the key structural alteration in pulmonary arterial hypertension associated with congenital heart disease (CHD). Changes in the pulmonary vessels in CHD generally occur in the inner and middle coats. This review considers the pathology of these changes and highlights some issues of a stereological approach to the morphometry of pulmonary vasculature. It also touches upon the issues of the morphology of pulmonary vessels in post-capillary and segmental pulmonary hypertension.
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Khugaev et al. (2021) conducted a review in Pulmonary arterial hypertension associated with congenital heart disease. This review highlights the pathology of pulmonary vascular remodeling in congenital heart disease and issues with stereological approaches to pulmonary vasculature morphometry.
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