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November 1, 2017OncoTargets and TherapyOpen Access

Primary site surgery for metastatic adrenocortical carcinoma improves survival outcomes: an analysis of a population-based database

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Key result

Primary site surgery significantly improved overall survival in patients with metastatic adrenocortical carcinoma compared to no surgery (HR 0.413; 95% CI 0.299-0.571; P<0.01).

Why the study?

Does primary site surgery improve survival in patients with metastatic adrenocortical carcinoma?

Population

290 metastatic adrenocortical carcinoma patients from the SEER database

Comparison

Primary site surgery vs No primary site surgery

Design

Cohort

Follow-up

median survival time 7 months

Authors

SWSen WangWGWeicheng GaoSCSansan Chen

Discussion

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Member takes

Overview

Hypothesis-generating for primary site surgery in metastatic adrenocortical carcinoma; prospective randomized trials needed before clinical adoption.

Study Design

Type

Cohort (n=290)

Multicenter

Yes

Structured PICO

Does primary site surgery improve survival in patients with metastatic adrenocortical carcinoma?

P
Population
290 patients with stage IV metastatic adrenocortical carcinoma identified from a population-based database, of whom 118 received primary site surgery.
E
Exposure
Primary site surgery (surgery of primary adrenal malignant lesions)
C
Comparator
No primary site surgery
O
Outcome
Overall survival and cancer-specific survivalhard clinical

Main Result

Hazard Ratio: 0.413 (95% CI 0.299–0.571)

p-value: p=<0.01

Primary site surgery in metastatic adrenocortical carcinoma is associated with significantly improved overall and cancer-specific survival.

Limitations

  • Retrospective database design
  • Requires prospective multicenter validation

Cite This Study

Wang et al. (2017) conducted a cohort in Metastatic adrenocortical carcinoma (ACC) (n=290). Primary site surgery vs. No primary site surgery was evaluated on Overall survival (HR 0.413, 95% CI 0.299-0.571, p=<0.01). Primary site surgery significantly improved overall survival in patients with metastatic adrenocortical carcinoma compared to no surgery (HR 0.413; 95% CI 0.299-0.571; P<0.01).

synapsesocial.com/papers/6a71c85c6c240de38cdc3acbhttps://doi.org/10.2147/ott.s147352
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Adrenal Surgery for Synchronously Metastatic Adrenocortical Carcinoma: A Population‐Based Analysis2021 · 7 citations
  2. 2Surgical management of metastatic adrenocortical carcinoma2023 · 6 citations
  3. 3Operative management for recurrent and metastatic adrenocortical carcinoma2011 · 101 citations
  4. 4A retrospective cohort study of surgery for adrenocortical carcinoma in a tertiary endocrine surgery unit2026
  5. 5Diagnosis, treatment and outcome of adrenocortical cancer2015 · 56 citations