Key result
Young patients with stage I arterial hypertension exhibited significantly increased arterial rigidity, including a higher carotid artery acceleration index (10.19 vs 8.27 m/s) compared to healthy controls.
Why the study?
Does increased blood pressure variability worsen arterial rigidity and endothelial dysfunction in young patients with early-stage arterial hypertension?
Cross-Sectional (n=58)
Does increased blood pressure variability worsen arterial rigidity and endothelial dysfunction in young patients with early-stage arterial hypertension?
Arterial rigidity parameters are sensitive early markers of endothelial dysfunction in young patients with stage I hypertension, especially those with increased blood pressure variability, even before structural vascular changes occur.
Answers are grounded in this paper and cite their sources.
Arterial rigidity measures may flag early endothelial dysfunction in young stage I hypertension; leaves open BP variability role, needing longitudinal confirmation.
The main topic of the article is the assessment of the endothelial dysfunction and the rigidity of arterial wall in the small, medium and large vessels in young patients with short anamnesis of hypertension and with different variability of blood pressure (BP). In young patients even at the beginning of arterial hypertension (AH) the disturbance in rigidity of arterial walls in great and peripheral vessels occurs. The increased variability of BP in young patients with AH is an aggravating factor of the arterial rigidity disturbances. The assessment of arterial rigidity in young patients at the early stages of the disease can elicit the early signs of endothelial dysfunction
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Brojaka et al. (2008) conducted a cross-sectional in Arterial hypertension (n=58). Stage I arterial hypertension vs. Healthy normotensive controls was evaluated on Acceleration index (AI) on carotid artery (p=<0.05). Young patients with stage I arterial hypertension exhibited significantly increased arterial rigidity, including a higher carotid artery acceleration index (10.19 vs 8.27 m/s) compared to healthy controls.
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