Key result
Severe hypertension linked to impaired PWV and augmentation index, supporting early stiffness assessment in resistant patients.
Why the study?
Good understanding of the pathophysiological mechanisms of resistant hypertension and their relationship to vascular dysfunction is important for optimal blood pressure control.
Does noninvasive assessment of arterial stiffness (PWV and AIx) provide useful prognostic information in patients with resistant hypertension?
Does noninvasive assessment of arterial stiffness (PWV and AIx) provide useful prognostic information in patients with resistant hypertension?
Noninvasive assessment of arterial stiffness via PWV and AIx may be valuable for early risk stratification in patients with resistant hypertension.
May support arterial stiffness assessment for risk stratification in resistant hypertension; leaves open need for prospective validation.
BACKGROUND Good understanding of the pathophysiological mechanism(s) of resistant hypertension (RH) and the relationship to vascular dysfunction is important for optimal blood pressure control. METHODS AND RESULTS The aim of this review article is to summarize the available data on the methods of arterial stiffness assessment, and their usefulness in RH. Several studies that provide information on the noninvasive methods of evaluation of arterial stiffness have been discussed; specifically, pulse wave velocity (PWV) and augmentation index (AIx) tests. Increased arterial stiffness, elevated AIx, and impaired endothelial function all act as indicators and predictors of cardiovascular events in patients with hypertension (HTN). CONCLUSION Our review suggests that PWV and AIx are impaired in patients with severe HTN. Early assessment of these characteristics can potentially be of value in patients with RH.
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Alsharari et al. (2019) conducted a review in Resistant hypertension. Arterial stiffness assessment (PWV and AIx) was evaluated. Pulse wave velocity and augmentation index are impaired in patients with severe hypertension, suggesting early assessment of arterial stiffness may be valuable in resistant hypertension.
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