Key result
Low-dose intravenous ketamine reduced the incidence of intraoperative nausea to 20% compared to 38.33% with placebo in women undergoing caesarean section under spinal anaesthesia.
Why the study?
Intraoperative nausea and vomiting remains an important clinical problem during caesarean section under regional anaesthesia, warranting further investigation into potential therapies such as low-dose ketamine.
Does low-dose ketamine reduce intraoperative nausea and vomiting in pregnant women undergoing elective caesarean section under spinal anaesthesia?
Population
120 patients undergoing caesarean section under spinal anaesthesia
Comparison
Intravenous low-dose ketamine (0.5 mg/kg over 20 min) vs normal saline placebo
Design
Randomized comparative study
Authors
Loading...
May warrant evaluation as antiemetic adjunct in caesarean under spinal anesthesia; leaves open confirmation in larger randomized trials.
RCT (n=120)
Double-blind
Computer generated randomization table
No
Does low-dose ketamine reduce intraoperative nausea and vomiting in pregnant women undergoing elective caesarean section under spinal anaesthesia?
Absolute Event Rate: 20% vs 38.33%
p-value: p=0.176
Low-dose intravenous ketamine may reduce the incidence of intraoperative nausea during elective caesarean section under spinal anaesthesia, though the statistical methodology reported is highly unconventional.
Haque et al. (2020) conducted an RCT in Intraoperative nausea and vomiting (n=120). Ketamine vs. Placebo (normal saline) was evaluated on Incidence of intraoperative nausea (p=0.176). Low-dose intravenous ketamine reduced the incidence of intraoperative nausea to 20% compared to 38.33% with placebo in women undergoing caesarean section under spinal anaesthesia.