Key result
Low dose ketamine (0.4 mg/kg) and dexamethasone (8 mg) reduced intraoperative nausea and vomiting compared to placebo, with ketamine also significantly reducing hypotensive episodes (P=0.02).
Why the study?
Does low dose ketamine reduce intraoperative nausea and vomiting in full term parturient women undergoing cesarean section under spinal anesthesia?
Population
135 full term parturient women of ASA I & II, aged between 20 and 40 years with uncomplicated pregnancies…
Comparison
0.4 mg/kg ketamine slowly IV immediately after… vs 8 mg dexamethasone slowly IV or 5 ml normal…
Design
Other
Follow-up
intraoperative
Authors
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May support low-dose ketamine for IONV prevention in spinal cesarean; hypothesis-generating and requires larger RCTs before practice change.
RCT (n=135)
Does low dose ketamine reduce intraoperative nausea and vomiting in full term parturient women undergoing cesarean section under spinal anesthesia?
Low dose ketamine is as effective as dexamethasone in preventing intraoperative nausea and vomiting during cesarean section under spinal anesthesia, and may reduce hypotensive episodes.
Hassanein et al. (2014) conducted an RCT in Intraoperative nausea and vomiting during cesarean section (n=135). Low dose ketamine vs. Dexamethasone (8 mg) or normal saline (placebo) was evaluated on Number of episodes of nausea and vomiting. Low dose ketamine (0.4 mg/kg) and dexamethasone (8 mg) reduced intraoperative nausea and vomiting compared to placebo, with ketamine also significantly reducing hypotensive episodes (P=0.02).
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