Key result
Azelnidipine combined with olmesartan decreased day-by-day home systolic blood pressure variability more than hydrochlorothiazide combined with olmesartan (6.3 vs 7.1 mm Hg; P=0.007).
Why the study?
Does azelnidipine reduce day-by-day home blood pressure variability more than hydrochlorothiazide in hypertensive subjects treated with olmesartan?
Population
207 hypertensive subjects treated with olmesartan monotherapy for 12 weeks
Comparison
Azelnidipine added to olmesartan for 24 weeks vs Hydrochlorothiazide added to olmesartan for 24…
Design
RCT, randomly assigned
Follow-up
24 weeks
Authors
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Supports CCB over diuretic add-on to olmesartan for lowering home SBP variability; extends evidence for ARB-CCB combinations in hypertension.
RCT (n=207)
Randomly assigned
Does azelnidipine reduce day-by-day home blood pressure variability more than hydrochlorothiazide in hypertensive subjects treated with olmesartan?
Absolute Event Rate: 6.3% vs 7.1%
p-value: p=0.007
The combination of an ARB and a CCB reduces day-by-day home blood pressure variability more effectively than an ARB and a diuretic, partly due to reductions in arterial stiffness.
Matsui et al. (2012) conducted an RCT in Hypertension (n=207). Azelnidipine vs. Hydrochlorothiazide was evaluated on Day-by-day home blood pressure variability (within-individual SD of the 5-day home systolic BP) (p=0.007). Azelnidipine combined with olmesartan decreased day-by-day home systolic blood pressure variability more than hydrochlorothiazide combined with olmesartan (6.3 vs 7.1 mm Hg; P=0.007).
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