Why the study?
What are the acute hemodynamic and electrocardiographic effects of graded IV doses of amiodarone in healthy anesthetized dogs?
What are the acute hemodynamic and electrocardiographic effects of graded IV doses of amiodarone in healthy anesthetized dogs?
This preclinical study aimed to determine an optimal IV dose of amiodarone that minimizes left ventricular dysfunction and arrhythmogenesis in a canine model.
Supports further canine dosing studies; leaves open clinical translation in veterinary practice.
This research was designed to study acute hemodynamic and electrocardiographic effects of amiodarone and to determine an IV dose of amiodarone that minimally affects left ventricular function and does not increase the tendency for ventricular arrhythmia.
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Bicer et al. (2000) studied this question.
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